Gordon S Mitchell

Gordon S Mitchell, Ph.D.

PROF

Department: HP-PHYSICAL THERAPY
Business Phone: (352) 273-6085
Business Email: gsmitche@phhp.ufl.edu

About Gordon S Mitchell

Dr. Mitchell joined the University of Florida in 2015 as a Preeminence Professor of Neuroscience in the Department of Physical Therapy and McKnight Brain Institute. He opened and directs the UF Center for Breathing Research and Therapeutics (BREATHE) and an NIH-funded graduate and postdoctoral training program of the same name. A major focus of BREATHE is to understand and treat impaired breathing and airway defense (swallowing/cough) caused by neuromuscular injury or disease. For the past three decades, Dr. Mitchell pioneered studies of neuroplasticity in the neural system controlling breathing. Areas of active investigation include: cellular and molecular mechanisms of long-lasting motor plasticity triggered by repeated exposure to low oxygen (intermittent hypoxia), the ability to harness that intermittent hypoxia-induced plasticity to treat respiratory and non-respiratory paralysis following spinal injury, mechanisms of spontaneous and induced compensation during motor neuron diseases such as ALS, cell-based strategies to treat breathing deficits, and the impact of systemic inflammation on breathing and its control. Investigations span intracellular, intercellular and physiological systems level mechanisms, and translation to humans with traumatic and neurodegenerative clinical disorders (SCI and ALS). Dr. Mitchell grew up in California where he received his B.S. (biological sciences) and PhD (Developmental and Cell Biology) degrees from the University of California at Irvine. After two years of post-doctoral training at the Max Planck Institute for Experimental Medicine in Gottingen, Germany, he moved to the University of Wisconsin-Madison where he became an Assistant Professor. There, he ascended the ranks to become Professor and Chair of the Department of Comparative Biosciences (17 years) and director of the NIH funded Respiratory Neurobiology Training Program (14 years). He chose to leave the University of Wisconsin for the opportunity to join the University of Florida and create BREATHE (formerly known as the Center for Respiratory Research and Rehabilitation, or CRRR). Dr. Mitchell has been recognized for both his research and teaching accomplishments, including a National Institutes of Health MERIT Award, the Norden Distinguished Teacher Award, the Pfizer Research Award on multiple occasions, the Steenbock Professorship for Behavioral and Neural Science, and distinguished lectureships from the Society for Neuroscience (SFN), American Physiological Society (APS), Association of Chairs of Departments of Physiology (ACDP), and the American Spinal Injury Association (ASIA).

Research Profile

Areas of Interest
  • ALS
  • Intermittent hypoxia
  • Neuroplasticity
  • Respiratory physiology
  • Sleep apnea
  • Spinal cord injury rehabilitation

Publications

2022
Acute intermittent hypoxia and respiratory muscle recruitment in people with amyotrophic lateral sclerosis: A preliminary study.
Experimental neurology. 347 [DOI] 10.1016/j.expneurol.2021.113890. [PMID] 34624328.
2022
Daily acute intermittent hypoxia enhances serotonergic innervation of hypoglossal motor nuclei in rats with and without cervical spinal injury.
Experimental neurology. 347 [DOI] 10.1016/j.expneurol.2021.113903. [PMID] 34699788.
2022
Therapeutic acute intermittent hypoxia: A translational roadmap for spinal cord injury and neuromuscular disease.
Experimental neurology. 347 [DOI] 10.1016/j.expneurol.2021.113891. [PMID] 34637802.
2021
Acute intermittent hypoxia boosts spinal plasticity in humans with tetraplegia.
Experimental neurology. 335 [DOI] 10.1016/j.expneurol.2020.113483. [PMID] 32987000.
2021
Acute morphine blocks spinal respiratory motor plasticity via long-latency mechanisms that require toll-like receptor 4 signalling.
The Journal of physiology. 599(15):3771-3797 [DOI] 10.1113/JP281362. [PMID] 34142718.
2021
Baseline Arterial CO2 Pressure Regulates Acute Intermittent Hypoxia-Induced Phrenic Long-Term Facilitation in Rats.
Frontiers in physiology. 12 [DOI] 10.3389/fphys.2021.573385. [PMID] 33716760.
2021
Cervical spinal injury compromises caudal spinal tissue oxygenation and undermines acute intermittent hypoxia-induced phrenic long-term facilitation.
Experimental neurology. 342 [DOI] 10.1016/j.expneurol.2021.113726. [PMID] 33915165.
2021
Crossing the blood-brain barrier with carbon dots: uptake mechanism and in vivo cargo delivery.
Nanoscale advances. 3(13):3942-3953 [DOI] 10.1039/d1na00145k. [PMID] 34263140.
2021
Daily acute intermittent hypoxia enhances phrenic motor output and stimulus-evoked phrenic responses in rats.
Journal of neurophysiology. 126(3):777-790 [DOI] 10.1152/jn.00112.2021. [PMID] 34260289.
2021
Effect of acute intermittent hypoxia on cortico-diaphragmatic conduction in healthy humans.
Experimental neurology. 339 [DOI] 10.1016/j.expneurol.2021.113651. [PMID] 33607080.
2021
Efficacy and time course of acute intermittent hypoxia effects in the upper extremities of people with cervical spinal cord injury.
Experimental neurology. 342 [DOI] 10.1016/j.expneurol.2021.113722. [PMID] 33932397.
2021
Phrenic motor neuron survival below cervical spinal cord hemisection.
Experimental neurology. 346 [DOI] 10.1016/j.expneurol.2021.113832. [PMID] 34363808.
2021
Prolonged acute intermittent hypoxia improves forelimb reach-to-grasp function in a rat model of chronic cervical spinal cord injury.
Experimental neurology. 340 [DOI] 10.1016/j.expneurol.2021.113672. [PMID] 33652030.
2021
Protocol-Specific Effects of Intermittent Hypoxia Pre-Conditioning on Phrenic Motor Plasticity in Rats with Chronic Cervical Spinal Cord Injury.
Journal of neurotrauma. 38(9):1292-1305 [DOI] 10.1089/neu.2020.7324. [PMID] 33446048.
2021
Serotonergic innervation of respiratory motor nuclei after cervical spinal injury: Impact of intermittent hypoxia.
Experimental neurology. 338 [DOI] 10.1016/j.expneurol.2021.113609. [PMID] 33460645.
2021
Silent hypoxaemia in COVID-19 patients.
The Journal of physiology. 599(4):1057-1065 [DOI] 10.1113/JP280769. [PMID] 33347610.
2021
Single-session effects of acute intermittent hypoxia on breathing function after human spinal cord injury.
Experimental neurology. 342 [DOI] 10.1016/j.expneurol.2021.113735. [PMID] 33951477.
2021
Systemic inflammation suppresses spinal respiratory motor plasticity via mechanisms that require serine/threonine protein phosphatase activity.
Journal of neuroinflammation. 18(1) [DOI] 10.1186/s12974-021-02074-6. [PMID] 33468163.
2021
The influence of intermittent hypoxia, obesity, and diabetes on male genitourinary anatomy and voiding physiology.
American journal of physiology. Renal physiology. 321(1):F82-F92 [DOI] 10.1152/ajprenal.00112.2021. [PMID] 34121451.
2020
Adenosine 2A receptor inhibition protects phrenic motor neurons from cell death induced by protein synthesis inhibition.
Experimental neurology. 323 [DOI] 10.1016/j.expneurol.2019.113067. [PMID] 31629857.
2020
Circadian clock genes and respiratory neuroplasticity genes oscillate in the phrenic motor system.
American journal of physiology. Regulatory, integrative and comparative physiology. 318(6):R1058-R1067 [DOI] 10.1152/ajpregu.00010.2020. [PMID] 32348679.
2020
Editorial: Neuromodulatory Control of Brainstem Function in Health and Disease.
Frontiers in neuroscience. 14 [DOI] 10.3389/fnins.2020.00086. [PMID] 32116528.
2020
Hypoxia-induced hypotension elicits adenosine-dependent phrenic long-term facilitation after carotid denervation.
Experimental neurology. 333 [DOI] 10.1016/j.expneurol.2020.113429. [PMID] 32735873.
2020
Mild to Moderate Sleep Apnea Is Linked to Hypoxia-induced Motor Recovery after Spinal Cord Injury.
American journal of respiratory and critical care medicine. 202(6):887-890 [DOI] 10.1164/rccm.202002-0245LE. [PMID] 32369393.
2020
Reliability of diaphragmatic motor-evoked potentials induced by transcranial magnetic stimulation.
Journal of applied physiology (Bethesda, Md. : 1985). 129(6):1393-1404 [DOI] 10.1152/japplphysiol.00486.2020. [PMID] 33031020.
2020
Spinal AMP kinase activity differentially regulates phrenic motor plasticity.
Journal of applied physiology (Bethesda, Md. : 1985). 128(3):523-533 [DOI] 10.1152/japplphysiol.00546.2019. [PMID] 31971473.
2020
Synergy between Acute Intermittent Hypoxia and Task-Specific Training.
Exercise and sport sciences reviews. 48(3):125-132 [DOI] 10.1249/JES.0000000000000222. [PMID] 32412926.
2019
Cancer cachexia impairs neural respiratory drive in hypoxia but not hypercapnia.
Journal of cachexia, sarcopenia and muscle. 10(1):63-72 [DOI] 10.1002/jcsm.12348. [PMID] 30362273.
2019
Cervical spinal 5-HT2A and 5-HT2B receptors are both necessary for moderate acute intermittent hypoxia-induced phrenic long-term facilitation.
Journal of applied physiology (Bethesda, Md. : 1985). 127(2):432-443 [DOI] 10.1152/japplphysiol.01113.2018. [PMID] 31219768.
2019
Cervical spinal contusion alters Na+-K+-2Cl- and K+-Cl- cation-chloride cotransporter expression in phrenic motor neurons.
Respiratory physiology & neurobiology. 261:15-23 [DOI] 10.1016/j.resp.2018.12.009. [PMID] 30590202.
2019
Circulatory control of phrenic motor plasticity.
Respiratory physiology & neurobiology. 265:19-23 [DOI] 10.1016/j.resp.2019.01.004. [PMID] 30639504.
2019
Mechanisms of compensatory plasticity for respiratory motor neuron death.
Respiratory physiology & neurobiology. 265:32-39 [DOI] 10.1016/j.resp.2019.01.001. [PMID] 30625378.
2019
Prednisolone Pretreatment Enhances Intermittent Hypoxia-Induced Plasticity in Persons With Chronic Incomplete Spinal Cord Injury.
Neurorehabilitation and neural repair. 33(11):911-921 [DOI] 10.1177/1545968319872992. [PMID] 31524075.
2019
Protein kinase Cδ constrains the S-pathway to phrenic motor facilitation elicited by spinal 5-HT7 receptors or severe acute intermittent hypoxia.
The Journal of physiology. 597(2):481-498 [DOI] 10.1113/JP276731. [PMID] 30382587.
2018
Acute intermittent hypoxia enhances corticospinal synaptic plasticity in humans.
eLife. 7 [DOI] 10.7554/eLife.34304. [PMID] 29688171.
2018
Compensatory plasticity in diaphragm and intercostal muscle utilization in a rat model of ALS.
Experimental neurology. 299(Pt A):148-156 [DOI] 10.1016/j.expneurol.2017.10.015. [PMID] 29056361.
2018
Cross-talk inhibition between 5-HT2B and 5-HT7 receptors in phrenic motor facilitation via NADPH oxidase and PKA.
American journal of physiology. Regulatory, integrative and comparative physiology. 314(5):R709-R715 [DOI] 10.1152/ajpregu.00393.2017. [PMID] 29384698.
2018
Cyclooxygenase enzyme activity does not impair respiratory motor plasticity after one night of intermittent hypoxia.
Respiratory physiology & neurobiology. 256:21-28 [DOI] 10.1016/j.resp.2017.12.004. [PMID] 29233741.
2018
Intermittent but not sustained moderate hypoxia elicits long-term facilitation of hypoglossal motor output.
Respiratory physiology & neurobiology. 256:15-20 [DOI] 10.1016/j.resp.2017.10.005. [PMID] 29074449.
2018
Pharmacological modulation of hypoxia-induced respiratory neuroplasticity.
Respiratory physiology & neurobiology. 256:4-14 [DOI] 10.1016/j.resp.2017.11.008. [PMID] 29197629.
2018
Phrenic motor neuron adenosine 2A receptors elicit phrenic motor facilitation.
The Journal of physiology. 596(8):1501-1512 [DOI] 10.1113/JP275462. [PMID] 29388230.
2018
Spinal activation of protein kinase C elicits phrenic motor facilitation.
Respiratory physiology & neurobiology. 256:36-42 [DOI] 10.1016/j.resp.2017.10.007. [PMID] 29081358.
2018
Spinal protein phosphatase 1 constrains respiratory plasticity after sustained hypoxia.
Journal of applied physiology (Bethesda, Md. : 1985). 125(5):1440-1446 [DOI] 10.1152/japplphysiol.00641.2018. [PMID] 30161006.
2018
Systemic inflammation inhibits serotonin receptor 2-induced phrenic motor facilitation upstream from BDNF/TrkB signaling.
Journal of neurophysiology. 119(6):2176-2185 [DOI] 10.1152/jn.00378.2017. [PMID] 29513151.
2017
Adenosine-dependent phrenic motor facilitation is inflammation resistant.
Journal of neurophysiology. 117(2):836-845 [DOI] 10.1152/jn.00619.2016. [PMID] 27927784.
2017
Effect of acute intermittent hypoxia on motor function in individuals with chronic spinal cord injury following ibuprofen pretreatment: A pilot study.
The journal of spinal cord medicine. 40(3):295-303 [DOI] 10.1080/10790268.2016.1142137. [PMID] 26856344.
2017
Effects of acute intermittent hypoxia on hand use after spinal cord trauma: A preliminary study.
Neurology. 89(18):1904-1907 [DOI] 10.1212/WNL.0000000000004596. [PMID] 28972191.
2017
Mechanisms of Enhanced Phrenic Long-Term Facilitation in SOD1G93A Rats.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 37(24):5834-5845 [DOI] 10.1523/JNEUROSCI.3680-16.2017. [PMID] 28500219.
2017
Phrenic motor neuron TrkB expression is necessary for acute intermittent hypoxia-induced phrenic long-term facilitation.
Experimental neurology. 287(Pt 2):130-136 [DOI] 10.1016/j.expneurol.2016.05.012. [PMID] 27185271.
2017
Respiratory neuroplasticity – Overview, significance and future directions.
Experimental neurology. 287(Pt 2):144-152 [DOI] 10.1016/j.expneurol.2016.05.022. [PMID] 27208699.
2017
Short-term modulation of the ventilatory response to exercise is preserved in obstructive sleep apnea.
Respiratory physiology & neurobiology. 236:42-50 [DOI] 10.1016/j.resp.2016.11.003. [PMID] 27840272.
2017
Special Issue: Respiratory Neuroplasticity.
Experimental neurology. 287(Pt 2):91-92 [DOI] 10.1016/j.expneurol.2016.11.004. [PMID] 27871363.
2017
Spinal BDNF-induced phrenic motor facilitation requires PKCθ activity.
Journal of neurophysiology. 118(5):2755-2762 [DOI] 10.1152/jn.00945.2016. [PMID] 28855298.
2016
Mechanisms of microglial activation in models of inflammation and hypoxia: Implications for chronic intermittent hypoxia.
The Journal of physiology. 594(6):1563-77 [DOI] 10.1113/JP271502. [PMID] 26890698.
2016
Quantitative assessment of integrated phrenic nerve activity.
Respiratory physiology & neurobiology. 226:81-6 [DOI] 10.1016/j.resp.2015.12.005. [PMID] 26724605.
2016
Sustained Hypoxia Elicits Competing Spinal Mechanisms of Phrenic Motor Facilitation.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 36(30):7877-85 [DOI] 10.1523/JNEUROSCI.4122-15.2016. [PMID] 27466333.
2015
Daily Acute Intermittent Hypoxia Elicits Functional Recovery of Diaphragm and Inspiratory Intercostal Muscle Activity After Acute Cervical Spinal Injury
Experimental Neurology. 266:1-10 [DOI] 10.1016/j.expneurol.2015.02.007. [PMID] 25687551.
2015
Intermittent hypoxia and neurorehabilitation.
Journal of applied physiology (Bethesda, Md. : 1985). 119(12):1455-65 [DOI] 10.1152/japplphysiol.00235.2015. [PMID] 25997947.
2015
Intermittent Hypoxia-Induced Spinal Inflammation Impairs Respiratory Motor Plasticity by a Spinal p38 MAP Kinase-Dependent Mechanism.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 35(17):6871-80 [DOI] 10.1523/JNEUROSCI.4539-14.2015. [PMID] 25926462.
2015
Mammalian target of rapamycin is required for phrenic long-term facilitation following severe but not moderate acute intermittent hypoxia.
Journal of neurophysiology. 114(3):1784-91 [DOI] 10.1152/jn.00539.2015. [PMID] 26224775.
2015
Phrenic long-term facilitation requires PKCθ activity within phrenic motor neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 35(21):8107-17 [DOI] 10.1523/JNEUROSCI.5086-14.2015. [PMID] 26019328.
2014
Adenosine 2A receptor inhibition enhances intermittent hypoxia-induced diaphragm but not intercostal long-term facilitation.
Journal of neurotrauma. 31(24):1975-84 [DOI] 10.1089/neu.2014.3393. [PMID] 25003645.
2014
Daily intermittent hypoxia enhances walking after chronic spinal cord injury: a randomized trial.
Neurology. 82(2):104-13 [DOI] 10.1212/01.WNL.0000437416.34298.43. [PMID] 24285617.
2014
Exercise training effects on hypoxic and hypercapnic ventilatory responses in mice selected for increased voluntary wheel running.
Experimental physiology. 99(2):403-13 [DOI] 10.1113/expphysiol.2013.076018. [PMID] 24142456.
2014
Spinal but not cortical microglia acquire an atypical phenotype with high VEGF, galectin-3 and osteopontin, and blunted inflammatory responses in ALS rats.
Neurobiology of disease. 69:43-53 [DOI] 10.1016/j.nbd.2013.11.009. [PMID] 24269728.
2014
Therapeutic potential of intermittent hypoxia: a matter of dose.
American journal of physiology. Regulatory, integrative and comparative physiology. 307(10):R1181-97 [DOI] 10.1152/ajpregu.00208.2014. [PMID] 25231353.
2013
Clinical challenges to ventilatory control.
Respiratory physiology & neurobiology. 189(2):211-2 [DOI] 10.1016/j.resp.2013.09.006. [PMID] 24056024.
2013
Common mechanisms of compensatory respiratory plasticity in spinal neurological disorders.
Respiratory physiology & neurobiology. 189(2):419-28 [DOI] 10.1016/j.resp.2013.05.025. [PMID] 23727226.
2013
Hypoxia Attenuates Purinergic P2X Receptor-Induced Inflammatory Gene Expression in Brainstem Microglia.
Hypoxia (Auckland, N.Z.). 2013(1) [DOI] 10.2147/HP.S45529. [PMID] 24377098.
2013
Hypoxia-induced phrenic long-term facilitation: emergent properties.
Annals of the New York Academy of Sciences. 1279:143-53 [DOI] 10.1111/nyas.12085. [PMID] 23531012.
2013
Intermittent hypoxia and stem cell implants preserve breathing capacity in a rodent model of amyotrophic lateral sclerosis.
American journal of respiratory and critical care medicine. 187(5):535-42 [DOI] 10.1164/rccm.201206-1072OC. [PMID] 23220913.
2013
Spinal vascular endothelial growth factor (VEGF) and erythropoietin (EPO) induced phrenic motor facilitation after repetitive acute intermittent hypoxia.
Respiratory physiology & neurobiology. 185(3):481-8 [DOI] 10.1016/j.resp.2012.10.014. [PMID] 23128070.
2012
7,8-dihydroxyflavone exhibits therapeutic efficacy in a mouse model of Rett syndrome.
Journal of applied physiology (Bethesda, Md. : 1985). 112(5):704-10 [DOI] 10.1152/japplphysiol.01361.2011. [PMID] 22194327.
2012
Cervical spinal erythropoietin induces phrenic motor facilitation via extracellular signal-regulated protein kinase and Akt signaling.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 32(17):5973-83 [DOI] 10.1523/JNEUROSCI.3873-11.2012. [PMID] 22539857.
2012
Exposure to acute intermittent hypoxia augments somatic motor function in humans with incomplete spinal cord injury.
Neurorehabilitation and neural repair. 26(2):163-72 [DOI] 10.1177/1545968311412055. [PMID] 21821826.
2012
Glial activation in the spinal ventral horn caudal to cervical injury.
Respiratory physiology & neurobiology. 180(1):61-8 [DOI] 10.1016/j.resp.2011.10.011. [PMID] 22041654.
2012
Increased GABA(A) receptor ε-subunit expression on ventral respiratory column neurons protects breathing during pregnancy.
PloS one. 7(1) [DOI] 10.1371/journal.pone.0030608. [PMID] 22303446.
2012
Repetitive acute intermittent hypoxia increases expression of proteins associated with plasticity in the phrenic motor nucleus.
Experimental neurology. 237(1):103-15 [DOI] 10.1016/j.expneurol.2012.05.020. [PMID] 22704858.
2012
Repetitive intermittent hypoxia induces respiratory and somatic motor recovery after chronic cervical spinal injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 32(11):3591-600 [DOI] 10.1523/JNEUROSCI.2908-11.2012. [PMID] 22423083.
2012
Severe acute intermittent hypoxia elicits phrenic long-term facilitation by a novel adenosine-dependent mechanism.
Journal of applied physiology (Bethesda, Md. : 1985). 112(10):1678-88 [DOI] 10.1152/japplphysiol.00060.2012. [PMID] 22403346.
2011
Lipopolysaccharide attenuates phrenic long-term facilitation following acute intermittent hypoxia.
Respiratory physiology & neurobiology. 176(3):130-5 [DOI] 10.1016/j.resp.2011.02.008. [PMID] 21334467.
2011
Reduced respiratory neural activity elicits phrenic motor facilitation.
Respiratory physiology & neurobiology. 175(3):303-9 [DOI] 10.1016/j.resp.2010.12.005. [PMID] 21167322.
2011
Short-term modulation of the exercise ventilatory response in younger and older women.
Respiratory physiology & neurobiology. 179(2-3):235-47 [DOI] 10.1016/j.resp.2011.08.011. [PMID] 21890003.
2011
Should we standardize protocols and preparations used to study respiratory plasticity?
Respiratory physiology & neurobiology. 177(2):93-7 [DOI] 10.1016/j.resp.2011.03.021. [PMID] 21470581.
2011
Spinal vascular endothelial growth factor induces phrenic motor facilitation via extracellular signal-regulated kinase and Akt signaling.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 31(21):7682-90 [DOI] 10.1523/JNEUROSCI.0239-11.2011. [PMID] 21613481.
2010
Multiple pathways to long-lasting phrenic motor facilitation.
Advances in experimental medicine and biology. 669:225-30 [DOI] 10.1007/978-1-4419-5692-7_45. [PMID] 20217354.
2010
Short- and long-term modulation of the exercise ventilatory response.
Medicine and science in sports and exercise. 42(9):1681-7 [DOI] 10.1249/MSS.0b013e3181d7b212. [PMID] 20164813.
2010
Short-term modulation of the exercise ventilatory response in older men.
Respiratory physiology & neurobiology. 173(1):37-46 [DOI] 10.1016/j.resp.2010.06.003. [PMID] 20601211.
2010
Spinal plasticity following intermittent hypoxia: implications for spinal injury.
Annals of the New York Academy of Sciences. 1198:252-9 [DOI] 10.1111/j.1749-6632.2010.05499.x. [PMID] 20536940.
2009
Breathing mechanics during exercise with added dead space reflect mechanisms of ventilatory control.
Respiratory physiology & neurobiology. 168(3):210-7 [DOI] 10.1016/j.resp.2009.07.001. [PMID] 19596464.
2009
Daily intermittent hypoxia augments spinal BDNF levels, ERK phosphorylation and respiratory long-term facilitation.
Experimental neurology. 217(1):116-23 [DOI] 10.1016/j.expneurol.2009.01.017. [PMID] 19416672.
2009
Developmental aspects of the upper airway: report from an NHLBI Workshop, March 5-6, 2009.
Proceedings of the American Thoracic Society. 6(6):513-20 [DOI] 10.1513/pats.200905-024CB. [PMID] 19741259.
2009
Intermittent hypoxia induces functional recovery following cervical spinal injury.
Respiratory physiology & neurobiology. 169(2):210-7 [DOI] 10.1016/j.resp.2009.07.023. [PMID] 19651247.
2008
Determinants of frequency long-term facilitation following acute intermittent hypoxia in vagotomized rats.
Respiratory physiology & neurobiology. 162(1):8-17 [DOI] 10.1016/j.resp.2008.03.005. [PMID] 18450525.
2008
Long-term effects of the perinatal environment on respiratory control.
Journal of applied physiology (Bethesda, Md. : 1985). 104(4):1220-9 [DOI] 10.1152/japplphysiol.01086.2007. [PMID] 18187608.
2008
Okadaic acid-sensitive protein phosphatases constrain phrenic long-term facilitation after sustained hypoxia.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 28(11):2949-58 [DOI] 10.1523/JNEUROSCI.5539-07.2008. [PMID] 18337426.
2008
Overview: the neurochemistry of respiratory control.
Respiratory physiology & neurobiology. 164(1-2):1-2 [DOI] 10.1016/j.resp.2008.07.021. [PMID] 18721910.
2008
Respiratory long-term facilitation: too much or too little of a good thing?
Advances in experimental medicine and biology. 605:224-7 [PMID] 18085276.
View on: PubMed
2008
Respiratory plasticity after perinatal hyperoxia is not prevented by antioxidant supplementation.
Respiratory physiology & neurobiology. 160(3):301-12 [PMID] 18069076.
View on: PubMed
2008
Short-term modulation of the exercise ventilatory response in young men.
Journal of applied physiology (Bethesda, Md. : 1985). 104(1):244-52 [PMID] 17991790.
View on: PubMed
2008
Simulated apnoeas induce serotonin-dependent respiratory long-term facilitation in rats.
The Journal of physiology. 586(8):2171-81 [DOI] 10.1113/jphysiol.2007.149047. [PMID] 18292130.
2008
Spinal adenosine A2a receptor activation elicits long-lasting phrenic motor facilitation.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 28(9):2033-42 [DOI] 10.1523/JNEUROSCI.3570-07.2008. [PMID] 18305238.
2007
Episodic stimulation of alpha1-adrenoreceptors induces protein kinase C-dependent persistent changes in motoneuronal excitability.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 27(16):4435-42 [PMID] 17442828.
View on: PubMed
2007
Is there a link between intermittent hypoxia-induced respiratory plasticity and obstructive sleep apnoea?
Experimental physiology. 92(1):27-37 [PMID] 17099064.
View on: PubMed
2006
Carotid sinus nerve responses and ventilatory acclimatization to hypoxia in adult rats following 2 weeks of postnatal hyperoxia.
Respiratory physiology & neurobiology. 150(2-3):155-64 [PMID] 15978876.
View on: PubMed
2006
Early postnatal chronic intermittent hypoxia modifies hypoxic respiratory responses and long-term phrenic facilitation in adult rats.
American journal of physiology. Regulatory, integrative and comparative physiology. 290(6):R1664-71 [PMID] 16455761.
View on: PubMed
2006
Layers of exercise hyperpnea: modulation and plasticity.
Respiratory physiology & neurobiology. 151(2-3):251-66 [PMID] 16530024.
View on: PubMed
2006
Recovery of phrenic activity and ventilation after cervical spinal hemisection in rats.
Journal of applied physiology (Bethesda, Md. : 1985). 100(3):800-6 [PMID] 16269524.
View on: PubMed
2006
Respiratory plasticity after perinatal hypercapnia in rats.
Respiratory physiology & neurobiology. 153(1):78-91 [PMID] 16338177.
View on: PubMed
2005
Carotid chemoafferent plasticity in adult rats following developmental hyperoxia.
Respiratory physiology & neurobiology. 145(1):3-11 [PMID] 15652783.
View on: PubMed
2005
Cervical spinal cord injury upregulates ventral spinal 5-HT2A receptors.
Journal of neurotrauma. 22(2):203-13 [PMID] 15716627.
View on: PubMed
2005
Differences in time-dependent hypoxic phrenic responses among inbred rat strains.
Journal of applied physiology (Bethesda, Md. : 1985). 98(3):838-44 [PMID] 15531560.
View on: PubMed
2005
Spinal synaptic enhancement with acute intermittent hypoxia improves respiratory function after chronic cervical spinal cord injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 25(11):2925-32 [PMID] 15772352.
View on: PubMed
2004
Back to the future: carbon dioxide chemoreceptors in the mammalian brain.
Nature neuroscience. 7(12):1288-90 [PMID] 15643436.
View on: PubMed
2004
BDNF is necessary and sufficient for spinal respiratory plasticity following intermittent hypoxia.
Nature neuroscience. 7(1):48-55 [PMID] 14699417.
View on: PubMed
2004
Breathing in thin air: acclimatization to altitude in ducks.
Respiratory physiology & neurobiology. 144(2-3):225-35 [PMID] 15556105.
View on: PubMed
2004
Concept mapping in pulmonary physiology using pathfinder scaling.
Advances in health sciences education : theory and practice. 9(3):225-40 [PMID] 15316273.
View on: PubMed
2003
Breathing: rhythmicity, plasticity, chemosensitivity.
Annual review of neuroscience. 26:239-66 [PMID] 12598679.
View on: PubMed
2003
Exercise increases hippocampal neurogenesis to high levels but does not improve spatial learning in mice bred for increased voluntary wheel running.
Behavioral neuroscience. 117(5):1006-16 [PMID] 14570550.
View on: PubMed
2003
Exercise-induced changes in hippocampal brain-derived neurotrophic factor and neurotrophin-3: effects of rat strain.
Brain research. 983(1-2):108-14 [PMID] 12914971.
View on: PubMed
2003
Intermittent hypoxia induces phrenic long-term facilitation in carotid-denervated rats.
Journal of applied physiology (Bethesda, Md. : 1985). 94(1):399-409 [PMID] 12391138.
View on: PubMed
2003
Neuroplasticity in respiratory motor control.
Journal of applied physiology (Bethesda, Md. : 1985). 94(1):358-74 [PMID] 12486024.
View on: PubMed
2003
Sex steroid hormones and the neural control of breathing.
Respiratory physiology & neurobiology. 136(2-3):249-63 [PMID] 12853015.
View on: PubMed
2003
Synaptic pathways to phrenic motoneurons are enhanced by chronic intermittent hypoxia after cervical spinal cord injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 23(7):2993-3000 [PMID] 12684486.
View on: PubMed
2002
Activity-dependent plasticity in descending synaptic inputs to respiratory spinal motoneurons.
Respiratory physiology & neurobiology. 131(1-2):79-90 [PMID] 12106997.
View on: PubMed
2002
Chronic cervical spinal sensory denervation reveals ineffective spinal pathways to phrenic motoneurons in the rat.
Neuroscience letters. 323(1):25-8 [PMID] 11911982.
View on: PubMed
2002
Phrenic long-term facilitation requires spinal serotonin receptor activation and protein synthesis.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 22(14):6239-46 [PMID] 12122082.
View on: PubMed
2002
Role of synaptic inhibition in turtle respiratory rhythm generation.
The Journal of physiology. 544(Pt 1):253-65 [PMID] 12356896.
View on: PubMed

Grants

Aug 2021 ACTIVE
Nanoparticle-Based Drug Delivery Targeting the Respiratory Neural Network
Role: Co-Investigator
Funding: NATL INST OF HLTH NINDS
May 2021 ACTIVE
Projections of opioid-sensitive KF neurons
Role: Other
Funding: NATL INST OF HLTH NIDA
Sep 2020 ACTIVE
Acute Intermittent Hypoxia to Improve Breathing in Humans with SCI
Role: Other
Funding: CRAIG H NEILSEN FOU
Jan 2020 ACTIVE
Microglial regulation of intermittent hypoxia induced phrenic motor plasticity
Role: Principal Investigator
Funding: NATL INST OF HLTH NHLBI
Jul 2019 ACTIVE
Regulation of Intermittent Hypoxia-Induced Respiratory Motor Plasticity
Role: Principal Investigator
Funding: NATL INST OF HLTH NHLBI
Jul 2019 – Apr 2021
Modulation of Respiratory Motor Plasticity Through Neuron- Microglia Interactions
Role: Other
Funding: PARKER B FRANCIS FELLOWSHIP FOU
Apr 2019 ACTIVE
Optimizing respiratory plasticity with chronic cervical SCI
Role: Principal Investigator
Funding: NATL INST OF HLTH NHLBI
Mar 2019 – Feb 2021
The Two Faces of Hypoxia in Alzheimer's Disease
Role: Principal Investigator
Funding: FL DEPT OF HLTH ED ETHEL MOORE ALZHEIMER
Sep 2018 ACTIVE
Acute Intermittent Hypoxia and Respiratory Strength Training to Improve Breathing Function after SCI
Role: Co-Investigator
Funding: US ARMY MED RES ACQUISITION
Aug 2018 ACTIVE
Ampakines and Respiratory Neuroplasticity
Role: Co-Investigator
Funding: NATL INST OF HLTH NHLBI
Feb 2018 – Aug 2018
Support for Intermittent Hypoxia Consortium (Conference)
Role: Principal Investigator
Funding: CRAIG H NEILSEN FOU
Nov 2017 ACTIVE
Chronic intermittent hypoxia-induced neuroinflammation undermines respiratory motor plasticity after chronic incomplete cervical spinal cord injury
Role: Co-Investigator
Funding: US ARMY MED RES AND DEVELOPMENT COMMAND
Jul 2017 – Oct 2021
Combinatorial Therapies to Treat Breathing Impairments After Cervical SCI
Role: Co-Investigator
Funding: CRAIG H NEILSEN FOU
Apr 2017 ACTIVE
Breathing Research and Therapeutics (BREATHE)
Role: Principal Investigator
Funding: NATL INST OF HLTH NHLBI
Sep 2016 ACTIVE
Functional mapping of peripheral and central circuits for airway protection and breathing
Role: Co-Investigator
Funding: NATL INST OF HLTH OD
Jun 2016 – May 2019
Mechanisms of intermittent hypoxia-induced motor recovery in persons with SCI
Role: Principal Investigator
Funding: EMORY UNIV via NATL INST OF HLTH
Apr 2016 – Mar 2020
MUSCLE STEM CELLS: NEW ALS GROWTH FACTOR THERAPY AND DISEASEMODEL
Role: Principal Investigator
Funding: UNIVERSITY OF WISCONSIN MADISON via NATL INST OF HLTH NINDS
Feb 2016 – Nov 2018
Recovery of breathing and forelimb function after prolonged exposure to repetitive acute intermittent hypoxia
Role: Principal Investigator
Funding: US ARMY MED RES ACQUISITION
Oct 2015 – Oct 2016
Therapeutic Intermittent Hypoxia and Functional Recovery of Respiration and Non-respiration Motor Function with Chronic, Incomplete SCI: a "Road Map" to Clinical Translation
Role: Principal Investigator
Funding: CRAIG H NEILSEN FOU
Jul 2015 – Jan 2020
Respiratory Plasticity and Spinal Cord Injury
Role: Principal Investigator
Funding: NATL INST OF HLTH NHLBI
Jan 2015 – Nov 2017
Intermittent Hypoxia-Induced Inflammation Modulates Respiratory Plasticity
Role: Principal Investigator
Funding: UNIVERSITY OF WISCONSIN MADISON via NATL INST OF HLTH NHLBI
Jul 2006 ACTIVE
BRAIN AND SPINAL CORD INJURY RESEARCH
Role: Project Manager
Funding: FL DEPT OF HLTH

Teaching Profile

Courses Taught
2019-2021
RSD7980 Research for Doctoral Dissertation
2017-2021
RSD7979 Advanced Research
2017-2021
PHT6168C Neurosci Phys Therapy
2016-2020
RSD6930 Special Topics in Rehabilitation Science
2020
RSD6940 Supervised Teaching
2019
EGN4912 Engineering Directed Independent Research
2018
GMS7980 Research for Doctoral Dissertation
2016-2017,2021
RSD6910 Supervised Research
2016-2017
RSD6905 Individual Work
2015
GMS7794 Neuroscience Seminar
2015
PHT6935C Seminar
2021
RSD6920 Rehabilitation Science Journal Club
2021
HSC4970 Public Health and Health Professions Senior Honors Thesis

Contact Details

Phones:
Business:
(352) 273-6085
Emails: