Sarah M Judge

Sarah M Judge,

Research Assistant Professor

Department: HP-PHYSICAL THERAPY
Business Phone: (352) 273-9146
Business Email: smsenf@ufl.edu

Teaching Profile

Courses Taught
2022-2023
PHT6153 Physiology for Pt

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0002-3974-0247

Areas of Interest
  • Aging
  • Cancer Cachexia
  • Muscle atrophy
  • Skeletal muscle wasting
  • muscle inactivity
  • pre-clinical models

Publications

2022
Biology of Activating Transcription Factor 4 (ATF4) and Its Role in Skeletal Muscle Atrophy.
The Journal of nutrition. 152(4):926-938 [DOI] 10.1093/jn/nxab440. [PMID] 34958390.
2022
Depleting Ly6G Positive Myeloid Cells Reduces Pancreatic Cancer-Induced Skeletal Muscle Atrophy.
Cells. 11(12) [DOI] 10.3390/cells11121893. [PMID] 35741022.
2022
Osteopenia is associated with wasting in pancreatic adenocarcinoma and predicts survival after surgery.
Cancer medicine. 11(1):50-60 [DOI] 10.1002/cam4.4416. [PMID] 34791809.
2021
FoxP1 is a transcriptional repressor associated with cancer cachexia that induces skeletal muscle wasting and weakness
Journal of Cachexia, Sarcopenia and Muscle. 12(2):421-442 [DOI] 10.1002/jcsm.12666. [PMID] 33527776.
2021
The Florida Pancreas Collaborative Next-Generation Biobank: Infrastructure to Reduce Disparities and Improve Survival for a Diverse Cohort of Patients with Pancreatic Cancer
Cancers. 13(4) [DOI] 10.3390/cancers13040809. [PMID] 33671939.
2020
Distinct cachexia profiles in response to human pancreatic tumours in mouse limb and respiratory muscle
Journal of Cachexia, Sarcopenia and Muscle. 11(3):820-837 [DOI] 10.1002/jcsm.12550. [PMID] 32039571.
2020
MEF2c-Dependent Downregulation of Myocilin Mediates Cancer-Induced Muscle Wasting and Associates with Cachexia in Patients with Cancer
Cancer Research. 80(9):1861-1874 [DOI] 10.1158/0008-5472.can-19-1558.
2020
Nicotine Induces IL-8 Secretion from Pancreatic Cancer Stroma and Worsens Cancer-Induced Cachexia.
Cancers. 12(2) [DOI] 10.3390/cancers12020329. [PMID] 32024069.
2019
IL-8 Released from Human Pancreatic Cancer and Tumor-Associated Stromal Cells Signals through a CXCR2-ERK1/2 Axis to Induce Muscle Atrophy.
Cancers. 11(12) [DOI] 10.3390/cancers11121863. [PMID] 31769424.
2019
Mas Receptor Activation Slows Tumor Growth and Attenuates Muscle Wasting in Cancer.
Cancer research. 79(4):706-719 [DOI] 10.1158/0008-5472.CAN-18-1207. [PMID] 30420474.
2018
Local and Systemic Cytokine Profiling for Pancreatic Ductal Adenocarcinoma to Study Cancer Cachexia in an Era of Precision Medicine.
International journal of molecular sciences. 19(12) [DOI] 10.3390/ijms19123836. [PMID] 30513792.
2018
Skeletal Muscle Fibrosis in Pancreatic Cancer Patients with Respect to Survival.
JNCI cancer spectrum. 2(3) [DOI] 10.1093/jncics/pky043. [PMID] 30637373.
2018
Tumour-derived leukaemia inhibitory factor is a major driver of cancer cachexia and morbidity in C26 tumour-bearing mice.
Journal of cachexia, sarcopenia and muscle. 9(6):1109-1120 [DOI] 10.1002/jcsm.12346. [PMID] 30270531.
2017
A clinically applicable muscular index predicts long-term survival in resectable pancreatic cancer.
Surgery. 161(4):930-938 [DOI] 10.1016/j.surg.2016.09.038. [PMID] 27932030.
2017
Human pancreatic cancer xenografts recapitulate key aspects of cancer cachexia.
Oncotarget. 8(1):1177-1189 [DOI] 10.18632/oncotarget.13593. [PMID] 27901481.
2017
Orthotopic Patient-Derived Pancreatic Cancer Xenografts Engraft Into the Pancreatic Parenchyma, Metastasize, and Induce Muscle Wasting to Recapitulate the Human Disease.
Pancreas. 46(6):813-819 [DOI] 10.1097/MPA.0000000000000843. [PMID] 28609371.
2015
Identification of the Acetylation and Ubiquitin-Modified Proteome during the Progression of Skeletal Muscle Atrophy.
PloS one. 10(8) [DOI] 10.1371/journal.pone.0136247. [PMID] 26302492.
2015
Inducible HSP70 is critical in preventing the aggregation and enhancing the processing of PMP22.
ASN neuro. 7(1) [DOI] 10.1177/1759091415569909. [PMID] 25694550.
2014
Genome-wide identification of FoxO-dependent gene networks in skeletal muscle during C26 cancer cachexia.
BMC cancer. 14 [DOI] 10.1186/1471-2407-14-997. [PMID] 25539728.
2014
HDAC1 activates FoxO and is both sufficient and required for skeletal muscle atrophy.
Journal of cell science. 127(Pt 7):1441-53 [DOI] 10.1242/jcs.136390. [PMID] 24463822.
2014
Transcriptional regulation of myotrophic actions by testosterone and trenbolone on androgen-responsive muscle.
Steroids. 87:59-66 [DOI] 10.1016/j.steroids.2014.05.024. [PMID] 24928725.
2013
Loss of the inducible Hsp70 delays the inflammatory response to skeletal muscle injury and severely impairs muscle regeneration.
PloS one. 8(4) [DOI] 10.1371/journal.pone.0062687. [PMID] 23626847.
2013
Skeletal muscle heat shock protein 70: Diverse functions and therapeutic potential for wasting disorders
Frontiers in Striated Muscle Physiology. 4(330)
2012
Inhibition of FoxO transcriptional activity prevents muscle fiber atrophy during cachexia and induces hypertrophy.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 26(3):987-1000 [DOI] 10.1096/fj.11-189977. [PMID] 22102632.
2011
Inhibition of IkappaB kinase alpha (IKKα) or IKKbeta (IKKβ) plus forkhead box O (Foxo) abolishes skeletal muscle atrophy.
Biochemical and biophysical research communications. 405(3):491-6 [DOI] 10.1016/j.bbrc.2011.01.059. [PMID] 21256828.
2011
p300 Acetyltransferase activity differentially regulates the localization and activity of the FOXO homologues in skeletal muscle.
American journal of physiology. Cell physiology. 300(6):C1490-501 [DOI] 10.1152/ajpcell.00255.2010. [PMID] 21389279.
2010
FOXO signaling is required for disuse muscle atrophy and is directly regulated by Hsp70.
American journal of physiology. Cell physiology. 298(1):C38-45 [DOI] 10.1152/ajpcell.00315.2009. [PMID] 19864323.
2010
Ros-mediated activation of NF-kappaB and Foxo during muscle disuse.
Muscle & nerve. 41(1):110-3 [DOI] 10.1002/mus.21526. [PMID] 19813194.
2009
Hsp27 inhibits IKKbeta-induced NF-kappaB activity and skeletal muscle atrophy.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 23(10):3415-23 [DOI] 10.1096/fj.08-124602. [PMID] 19528257.
2008
Hsp70 overexpression inhibits NF-kappaB and Foxo3a transcriptional activities and prevents skeletal muscle atrophy.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 22(11):3836-45 [DOI] 10.1096/fj.08-110163. [PMID] 18644837.

Grants

Aug 2022 ACTIVE
The Complement System and Cancer Cachexia
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAMS
May 2021 ACTIVE
Ursolic acid as a countermeasure to cancer cachexia
Role: Principal Investigator
Funding: FL DEPT OF HLTH BANKHEAD-COLEY CANCER RE
Sep 2017 ACTIVE
FoxO signaling and skeletal muscle atrophy
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAMS
Apr 2017 – Jun 2021
OoR CTSI Institutional Matching Support
Role: Project Manager
Funding: UF DIV OF SPONSORED RES MATCHING FUNDS
Mar 2017 – Dec 2020
Initiating Mechanisms of Cancer Cachexia
Role: Co-Investigator
Funding: FL DEPT OF HLTH BANKHEAD-COLEY CANCER RE

Education

PhD in Exercise Physiology/Skeletal Muscle Biology
2012 · University of Florida
Bachelor of Science in Microbiology and Cell Science
2006 · University of Florida

Contact Details

Phones:
Business:
(352) 273-9146
Emails:
Business:
smsenf@ufl.edu
Addresses:
Business Mailing:
PO Box 100154
GAINESVILLE FL 32610
Business Street:
1275 CENTER DR
GAINESVILLE FL 32610