Sarah M Judge,
Research Assistant Professor
Teaching Profile
Courses Taught
2022-2023
PHT6153 Physiology for Pt
2023
PHT6935C Seminar
Research Profile
Open Researcher and Contributor ID (ORCID)
0000-0002-3974-0247
Areas of Interest
- Cancer Cachexia
- Muscle atrophy
- Skeletal muscle wasting
- muscle inactivity
- pre-clinical models
Publications
2023
Blocking muscle wasting via deletion of the muscle-specific E3 ligase MuRF1 impedes pancreatic tumor growth.
Communications biology.
6(1)
[DOI] 10.1038/s42003-023-04902-2.
[PMID] 37179425.
2023
Blocking muscle wasting via deletion of the muscle-specific E3 ubiquitin ligase MuRF1 impedes pancreatic tumor growth.
Research square.
[DOI] 10.21203/rs.3.rs-2524562/v1.
[PMID] 36798266.
2023
Low Muscle Mass and Radiodensity Associate with Impaired Pulmonary Function and Respiratory Complications in Patients with Esophageal Cancer.
Journal of the American College of Surgeons.
236(4):677-684
[DOI] 10.1097/XCS.0000000000000535.
[PMID] 36728466.
2022
Biology of Activating Transcription Factor 4 (ATF4) and Its Role in Skeletal Muscle Atrophy.
The Journal of nutrition.
152(4):926-938
[DOI] 10.1093/jn/nxab440.
[PMID] 34958390.
2022
Depleting Ly6G Positive Myeloid Cells Reduces Pancreatic Cancer-Induced Skeletal Muscle Atrophy.
Cells.
11(12)
[DOI] 10.3390/cells11121893.
[PMID] 35741022.
2022
Osteopenia is associated with wasting in pancreatic adenocarcinoma and predicts survival after surgery.
Cancer medicine.
11(1):50-60
[DOI] 10.1002/cam4.4416.
[PMID] 34791809.
2021
FoxP1 is a transcriptional repressor associated with cancer cachexia that induces skeletal muscle wasting and weakness
Journal of Cachexia, Sarcopenia and Muscle.
12(2):421-442
[DOI] 10.1002/jcsm.12666.
[PMID] 33527776.
2021
The Florida Pancreas Collaborative Next-Generation Biobank: Infrastructure to Reduce Disparities and Improve Survival for a Diverse Cohort of Patients with Pancreatic Cancer
Cancers.
13(4)
[DOI] 10.3390/cancers13040809.
[PMID] 33671939.
2020
Distinct cachexia profiles in response to human pancreatic tumours in mouse limb and respiratory muscle
Journal of Cachexia, Sarcopenia and Muscle.
11(3):820-837
[DOI] 10.1002/jcsm.12550.
[PMID] 32039571.
2020
MEF2c-Dependent Downregulation of Myocilin Mediates Cancer-Induced Muscle Wasting and Associates with Cachexia in Patients with Cancer.
Cancer research.
80(9):1861-1874
[DOI] 10.1158/0008-5472.CAN-19-1558.
[PMID] 32132110.
2020
Nicotine Induces IL-8 Secretion from Pancreatic Cancer Stroma and Worsens Cancer-Induced Cachexia.
Cancers.
12(2)
[DOI] 10.3390/cancers12020329.
[PMID] 32024069.
2019
IL-8 Released from Human Pancreatic Cancer and Tumor-Associated Stromal Cells Signals through a CXCR2-ERK1/2 Axis to Induce Muscle Atrophy.
Cancers.
11(12)
[DOI] 10.3390/cancers11121863.
[PMID] 31769424.
2019
Mas Receptor Activation Slows Tumor Growth and Attenuates Muscle Wasting in Cancer.
Cancer research.
79(4):706-719
[DOI] 10.1158/0008-5472.CAN-18-1207.
[PMID] 30420474.
2018
Local and Systemic Cytokine Profiling for Pancreatic Ductal Adenocarcinoma to Study Cancer Cachexia in an Era of Precision Medicine.
International journal of molecular sciences.
19(12)
[DOI] 10.3390/ijms19123836.
[PMID] 30513792.
2018
Skeletal Muscle Fibrosis in Pancreatic Cancer Patients with Respect to Survival.
JNCI cancer spectrum.
2(3)
[DOI] 10.1093/jncics/pky043.
[PMID] 30637373.
2018
Tumour-derived leukaemia inhibitory factor is a major driver of cancer cachexia and morbidity in C26 tumour-bearing mice.
Journal of cachexia, sarcopenia and muscle.
9(6):1109-1120
[DOI] 10.1002/jcsm.12346.
[PMID] 30270531.
2017
A clinically applicable muscular index predicts long-term survival in resectable pancreatic cancer.
Surgery.
161(4):930-938
[DOI] 10.1016/j.surg.2016.09.038.
[PMID] 27932030.
2017
Human pancreatic cancer xenografts recapitulate key aspects of cancer cachexia.
Oncotarget.
8(1):1177-1189
[DOI] 10.18632/oncotarget.13593.
[PMID] 27901481.
2017
Orthotopic Patient-Derived Pancreatic Cancer Xenografts Engraft Into the Pancreatic Parenchyma, Metastasize, and Induce Muscle Wasting to Recapitulate the Human Disease.
Pancreas.
46(6):813-819
[DOI] 10.1097/MPA.0000000000000843.
[PMID] 28609371.
2015
Identification of the Acetylation and Ubiquitin-Modified Proteome during the Progression of Skeletal Muscle Atrophy.
PloS one.
10(8)
[DOI] 10.1371/journal.pone.0136247.
[PMID] 26302492.
2015
Inducible HSP70 is critical in preventing the aggregation and enhancing the processing of PMP22.
ASN neuro.
7(1)
[DOI] 10.1177/1759091415569909.
[PMID] 25694550.
2014
Genome-wide identification of FoxO-dependent gene networks in skeletal muscle during C26 cancer cachexia.
BMC cancer.
14
[DOI] 10.1186/1471-2407-14-997.
[PMID] 25539728.
2014
HDAC1 activates FoxO and is both sufficient and required for skeletal muscle atrophy.
Journal of cell science.
127(Pt 7):1441-53
[DOI] 10.1242/jcs.136390.
[PMID] 24463822.
2014
Transcriptional regulation of myotrophic actions by testosterone and trenbolone on androgen-responsive muscle.
Steroids.
87:59-66
[DOI] 10.1016/j.steroids.2014.05.024.
[PMID] 24928725.
2013
Loss of the inducible Hsp70 delays the inflammatory response to skeletal muscle injury and severely impairs muscle regeneration.
PloS one.
8(4)
[DOI] 10.1371/journal.pone.0062687.
[PMID] 23626847.
2013
Skeletal muscle heat shock protein 70: diverse functions and therapeutic potential for wasting disorders.
Frontiers in physiology.
4
[DOI] 10.3389/fphys.2013.00330.
[PMID] 24273516.
2012
Determination of gene promoter activity in skeletal muscles in vivo.
Methods in molecular biology (Clifton, N.J.).
798:461-72
[DOI] 10.1007/978-1-61779-343-1_27.
[PMID] 22130854.
2012
Inhibition of FoxO transcriptional activity prevents muscle fiber atrophy during cachexia and induces hypertrophy.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
26(3):987-1000
[DOI] 10.1096/fj.11-189977.
[PMID] 22102632.
2011
Inhibition of IkappaB kinase alpha (IKKα) or IKKbeta (IKKβ) plus forkhead box O (Foxo) abolishes skeletal muscle atrophy.
Biochemical and biophysical research communications.
405(3):491-6
[DOI] 10.1016/j.bbrc.2011.01.059.
[PMID] 21256828.
2011
p300 Acetyltransferase activity differentially regulates the localization and activity of the FOXO homologues in skeletal muscle.
American journal of physiology. Cell physiology.
300(6):C1490-501
[DOI] 10.1152/ajpcell.00255.2010.
[PMID] 21389279.
2010
FOXO signaling is required for disuse muscle atrophy and is directly regulated by Hsp70.
American journal of physiology. Cell physiology.
298(1):C38-45
[DOI] 10.1152/ajpcell.00315.2009.
[PMID] 19864323.
2010
Ros-mediated activation of NF-kappaB and Foxo during muscle disuse.
Muscle & nerve.
41(1):110-3
[DOI] 10.1002/mus.21526.
[PMID] 19813194.
2009
Hsp27 inhibits IKKbeta-induced NF-kappaB activity and skeletal muscle atrophy.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
23(10):3415-23
[DOI] 10.1096/fj.08-124602.
[PMID] 19528257.
2008
Hsp70 overexpression inhibits NF-kappaB and Foxo3a transcriptional activities and prevents skeletal muscle atrophy.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
22(11):3836-45
[DOI] 10.1096/fj.08-110163.
[PMID] 18644837.
Grants
May 2023
ACTIVE
Development of Novel Therapeutics for Cancer Cachexia
Role: Principal Investigator
Funding: EMMYON
via NATL INST OF HLTH NCI
Jan 2023
– Jun 2023
Conference Funding for Advances in Skeletal Muscle Biology in Health and Disease Conferences
Role: Principal Investigator
Funding: THE COMPANY OF BIOLOGISTS
Aug 2022
ACTIVE
The Complement System and Cancer Cachexia
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAMS
May 2021
ACTIVE
Ursolic acid as a countermeasure to cancer cachexia
Role: Principal Investigator
Funding: FL DEPT OF HLTH BANKHEAD-COLEY CANCER RE
Sep 2017
– Aug 2023
FoxO signaling and skeletal muscle atrophy
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAMS
Apr 2017
– Jun 2021
OoR CTSI Institutional Matching Support
Role: Project Manager
Funding: UF DIV OF SPONSORED RES MATCHING FUNDS
Mar 2017
– Dec 2020
Initiating Mechanisms of Cancer Cachexia
Role: Co-Investigator
Funding: FL DEPT OF HLTH BANKHEAD-COLEY CANCER RE
Education
PhD in Exercise Physiology/Skeletal Muscle Biology
2012
·
University of Florida
Bachelor of Science in Microbiology and Cell Science
2006
·
University of Florida
Contact Details
Phones:
- Business:
- (352) 273-9146
Emails:
- Business:
- smsenf@ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100154
GAINESVILLE FL 32610 - Business Street:
-
1275 CENTER DR
GAINESVILLE FL 32610