Sarah M Judge,
Research Assistant Professor
Teaching Profile
Courses Taught
2022-2024
PHT6153 Physiology for Pt
2023
PHT6935C Seminar
2024
PHT6157 Pathophysiology for Physical Therapy
2024
HSC4970 Public Health and Health Professions Senior Honors Thesis
Research Profile
Open Researcher and Contributor ID (ORCID)
0000-0002-3974-0247
Areas of Interest
- Cancer Cachexia
- Muscle atrophy
- Skeletal muscle wasting
- muscle inactivity
- pre-clinical models
Publications
2024
Heterogeneity of weight loss and transcriptomic signatures in pancreatic ductal adenocarcinoma.
Journal of cachexia, sarcopenia and muscle.
15(1):149-158
[DOI] 10.1002/jcsm.13390.
[PMID] 38123146.
2024
Mitochondrial fusion and altered beta-oxidation drive muscle wasting in a Drosophila cachexia model.
EMBO reports.
25(4):1835-1858
[DOI] 10.1038/s44319-024-00102-z.
[PMID] 38429578.
2024
Ursolic Acid Induces Beneficial Changes in Skeletal Muscle mRNA Expression and Increases Exercise Participation and Performance in Dogs with Age-Related Muscle Atrophy.
Animals : an open access journal from MDPI.
14(2)
[DOI] 10.3390/ani14020186.
[PMID] 38254356.
2023
Blocking muscle wasting via deletion of the muscle-specific E3 ligase MuRF1 impedes pancreatic tumor growth.
Communications biology.
6(1)
[DOI] 10.1038/s42003-023-04902-2.
[PMID] 37179425.
2023
Blocking muscle wasting via deletion of the muscle-specific E3 ubiquitin ligase MuRF1 impedes pancreatic tumor growth.
Research square.
[DOI] 10.21203/rs.3.rs-2524562/v1.
[PMID] 36798266.
2023
Low Muscle Mass and Radiodensity Associate with Impaired Pulmonary Function and Respiratory Complications in Patients with Esophageal Cancer.
Journal of the American College of Surgeons.
236(4):677-684
[DOI] 10.1097/XCS.0000000000000535.
[PMID] 36728466.
2022
Biology of Activating Transcription Factor 4 (ATF4) and Its Role in Skeletal Muscle Atrophy.
The Journal of nutrition.
152(4):926-938
[DOI] 10.1093/jn/nxab440.
[PMID] 34958390.
2022
Depleting Ly6G Positive Myeloid Cells Reduces Pancreatic Cancer-Induced Skeletal Muscle Atrophy.
Cells.
11(12)
[DOI] 10.3390/cells11121893.
[PMID] 35741022.
2022
Osteopenia is associated with wasting in pancreatic adenocarcinoma and predicts survival after surgery.
Cancer medicine.
11(1):50-60
[DOI] 10.1002/cam4.4416.
[PMID] 34791809.
2021
FoxP1 is a transcriptional repressor associated with cancer cachexia that induces skeletal muscle wasting and weakness
Journal of Cachexia, Sarcopenia and Muscle.
12(2):421-442
[DOI] 10.1002/jcsm.12666.
[PMID] 33527776.
2021
The Florida Pancreas Collaborative Next-Generation Biobank: Infrastructure to Reduce Disparities and Improve Survival for a Diverse Cohort of Patients with Pancreatic Cancer
Cancers.
13(4)
[DOI] 10.3390/cancers13040809.
[PMID] 33671939.
2020
Distinct cachexia profiles in response to human pancreatic tumours in mouse limb and respiratory muscle
Journal of Cachexia, Sarcopenia and Muscle.
11(3):820-837
[DOI] 10.1002/jcsm.12550.
[PMID] 32039571.
2020
MEF2c-Dependent Downregulation of Myocilin Mediates Cancer-Induced Muscle Wasting and Associates with Cachexia in Patients with Cancer.
Cancer research.
80(9):1861-1874
[DOI] 10.1158/0008-5472.CAN-19-1558.
[PMID] 32132110.
2020
Nicotine Induces IL-8 Secretion from Pancreatic Cancer Stroma and Worsens Cancer-Induced Cachexia.
Cancers.
12(2)
[DOI] 10.3390/cancers12020329.
[PMID] 32024069.
2019
IL-8 Released from Human Pancreatic Cancer and Tumor-Associated Stromal Cells Signals through a CXCR2-ERK1/2 Axis to Induce Muscle Atrophy.
Cancers.
11(12)
[DOI] 10.3390/cancers11121863.
[PMID] 31769424.
2019
Mas Receptor Activation Slows Tumor Growth and Attenuates Muscle Wasting in Cancer.
Cancer research.
79(4):706-719
[DOI] 10.1158/0008-5472.CAN-18-1207.
[PMID] 30420474.
2018
Local and Systemic Cytokine Profiling for Pancreatic Ductal Adenocarcinoma to Study Cancer Cachexia in an Era of Precision Medicine.
International journal of molecular sciences.
19(12)
[DOI] 10.3390/ijms19123836.
[PMID] 30513792.
2018
Skeletal Muscle Fibrosis in Pancreatic Cancer Patients with Respect to Survival.
JNCI cancer spectrum.
2(3)
[DOI] 10.1093/jncics/pky043.
[PMID] 30637373.
2018
Tumour-derived leukaemia inhibitory factor is a major driver of cancer cachexia and morbidity in C26 tumour-bearing mice.
Journal of cachexia, sarcopenia and muscle.
9(6):1109-1120
[DOI] 10.1002/jcsm.12346.
[PMID] 30270531.
2017
A clinically applicable muscular index predicts long-term survival in resectable pancreatic cancer.
Surgery.
161(4):930-938
[DOI] 10.1016/j.surg.2016.09.038.
[PMID] 27932030.
2017
Human pancreatic cancer xenografts recapitulate key aspects of cancer cachexia.
Oncotarget.
8(1):1177-1189
[DOI] 10.18632/oncotarget.13593.
[PMID] 27901481.
2017
Orthotopic Patient-Derived Pancreatic Cancer Xenografts Engraft Into the Pancreatic Parenchyma, Metastasize, and Induce Muscle Wasting to Recapitulate the Human Disease.
Pancreas.
46(6):813-819
[DOI] 10.1097/MPA.0000000000000843.
[PMID] 28609371.
2015
Identification of the Acetylation and Ubiquitin-Modified Proteome during the Progression of Skeletal Muscle Atrophy.
PloS one.
10(8)
[DOI] 10.1371/journal.pone.0136247.
[PMID] 26302492.
2015
Inducible HSP70 is critical in preventing the aggregation and enhancing the processing of PMP22.
ASN neuro.
7(1)
[DOI] 10.1177/1759091415569909.
[PMID] 25694550.
2014
Genome-wide identification of FoxO-dependent gene networks in skeletal muscle during C26 cancer cachexia.
BMC cancer.
14
[DOI] 10.1186/1471-2407-14-997.
[PMID] 25539728.
2014
HDAC1 activates FoxO and is both sufficient and required for skeletal muscle atrophy.
Journal of cell science.
127(Pt 7):1441-53
[DOI] 10.1242/jcs.136390.
[PMID] 24463822.
2014
Transcriptional regulation of myotrophic actions by testosterone and trenbolone on androgen-responsive muscle.
Steroids.
87:59-66
[DOI] 10.1016/j.steroids.2014.05.024.
[PMID] 24928725.
2013
Loss of the inducible Hsp70 delays the inflammatory response to skeletal muscle injury and severely impairs muscle regeneration.
PloS one.
8(4)
[DOI] 10.1371/journal.pone.0062687.
[PMID] 23626847.
2013
Skeletal muscle heat shock protein 70: diverse functions and therapeutic potential for wasting disorders.
Frontiers in physiology.
4
[DOI] 10.3389/fphys.2013.00330.
[PMID] 24273516.
2012
Determination of gene promoter activity in skeletal muscles in vivo.
Methods in molecular biology (Clifton, N.J.).
798:461-72
[DOI] 10.1007/978-1-61779-343-1_27.
[PMID] 22130854.
2012
Inhibition of FoxO transcriptional activity prevents muscle fiber atrophy during cachexia and induces hypertrophy.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
26(3):987-1000
[DOI] 10.1096/fj.11-189977.
[PMID] 22102632.
2011
Inhibition of IkappaB kinase alpha (IKKα) or IKKbeta (IKKβ) plus forkhead box O (Foxo) abolishes skeletal muscle atrophy.
Biochemical and biophysical research communications.
405(3):491-6
[DOI] 10.1016/j.bbrc.2011.01.059.
[PMID] 21256828.
2011
p300 Acetyltransferase activity differentially regulates the localization and activity of the FOXO homologues in skeletal muscle.
American journal of physiology. Cell physiology.
300(6):C1490-501
[DOI] 10.1152/ajpcell.00255.2010.
[PMID] 21389279.
2010
FOXO signaling is required for disuse muscle atrophy and is directly regulated by Hsp70.
American journal of physiology. Cell physiology.
298(1):C38-45
[DOI] 10.1152/ajpcell.00315.2009.
[PMID] 19864323.
2010
Ros-mediated activation of NF-kappaB and Foxo during muscle disuse.
Muscle & nerve.
41(1):110-3
[DOI] 10.1002/mus.21526.
[PMID] 19813194.
2009
Hsp27 inhibits IKKbeta-induced NF-kappaB activity and skeletal muscle atrophy.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
23(10):3415-23
[DOI] 10.1096/fj.08-124602.
[PMID] 19528257.
2008
Hsp70 overexpression inhibits NF-kappaB and Foxo3a transcriptional activities and prevents skeletal muscle atrophy.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
22(11):3836-45
[DOI] 10.1096/fj.08-110163.
[PMID] 18644837.
Grants
Sep 2023
ACTIVE
Matricellular proteins of the CNN family as regulators of tumor-induced cachexia
Role: Principal Investigator
Funding: NATL INST OF HLTH NCI
May 2023
ACTIVE
Development of Novel Therapeutics for Cancer Cachexia
Role: Principal Investigator
Funding: EMMYON
via NATL INST OF HLTH NCI
Jan 2023
– Jun 2023
Conference Funding for Advances in Skeletal Muscle Biology in Health and Disease Conferences
Role: Principal Investigator
Funding: THE COMPANY OF BIOLOGISTS
Aug 2022
ACTIVE
The Complement System and Cancer Cachexia
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAMS
May 2021
ACTIVE
Ursolic acid as a countermeasure to cancer cachexia
Role: Principal Investigator
Funding: FL DEPT OF HLTH BANKHEAD-COLEY CANCER RE
Sep 2017
– Aug 2023
FoxO signaling and skeletal muscle atrophy
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAMS
Apr 2017
– Jun 2021
OoR CTSI Institutional Matching Support
Role: Project Manager
Funding: UF DIV OF SPONSORED RES MATCHING FUNDS
Mar 2017
– Dec 2020
Initiating Mechanisms of Cancer Cachexia
Role: Co-Investigator
Funding: FL DEPT OF HLTH BANKHEAD-COLEY CANCER RE
Education
PhD in Exercise Physiology/Skeletal Muscle Biology
2012
·
University of Florida
Bachelor of Science in Microbiology and Cell Science
2006
·
University of Florida
Contact Details
Phones:
- Business:
- (352) 273-9146
Emails:
- Business:
- smsenf@ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100154
GAINESVILLE FL 32610 - Business Street:
-
1275 CENTER DR
GAINESVILLE FL 32610